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Introduction：
Product Name | D-Glucosamine hydrochloride |
Synonyms | Glucosamine HCL |
Appearance | White crystalline powder |
CAS | 66-84-2 |
Molecular formula | C6H14ClNO5 |
Molecular Weight | 215.63 |
Purity | 98%min Glucosamine hydrochloride |
Sample | Available |
D-Glucosamine hydrochloride is a potentiator for the treatment of osteoarthritic diseases and antibiotics, a sweetener and antioxidant for food, a nutritional supplement for diabetic patients, and a major raw material for the synthesis of a new type of anticancer drug, Chlorourethromycin, which can also inhibit the growth of cancer cells. Glucosamine hydrochloride and its derivatives have a wide range of application prospects in the fields of medicine, light industry and cosmetics.
Specification:
| Items | Specifications | Test Methods | Results |
| Properties(physical): | |||
| Appearance | White Crystalline, Free Flowing Powder | Visual | Complies |
| Odour | Odourless | Complies | |
| Bulk Density | NLT 0.45g/ml | USP2021 -- <616> | 0.54g/ml |
| As Tapped Density | Meets the requirements of USP2021 | USP2021 -- <616> | Complies |
| Particle Size | NLT 90% through 80 Mesh | USP2021 -- <811> | Complies |
| Analytical Properties: | |||
| Assay(HPLC) | 98.0 - 102.0% (on the dried basis) | USP2021 -- <621> | 98.52% |
| Identification: | |||
| A: Infrared Absorption | Meet the requirement | USP2021 -- <197K> | Complies |
| B: Tests for Chloride | Meet the requirement | USP2021 -- <191> | Complies |
| C: Retention time in the Assay | Corresponds to the reference standard | USP2021 -- <621> | Complies |
| Transm | NLT 90.0% (10.0%Water Solutate-450nm) | USP2021 -- <857> | 96.8% |
| Absorb | NMT 0.25a.u. (10.0%Water Solutate-280nm) | USP2021 -- <857> | 0.05 a.u. |
| Specific Rotation (α)²⁰ᴰ | +70.00°→+73.00° | USP2021 -- <781S> | +71.69° |
| pH (20mg/ml.aq.sol.) | 3.0 - 5.0 | USP2021 -- <791> | 4.32 |
| Loss on Drying | NMT 0.5% | USP2021 -- <731> | 0.08% |
| Residue on Ignition | NMT 0.1% | USP2021 -- <281> | 0.06% |
| Chloride (Cl) | 16.0% - 17.0% | USP2021 -- <541> | 16.61% |
| Sulfate | NMT 0.24% | USP2021 -- <221> | Complies |
| Heavy Metals | NMT 10 ppm | USP2021 -- <231>Ⅱ | Complies |
| Iron (fe) | NMT 10 ppm | USP2021 -- <241> | Complies |
| Lead (Pb) | NMT 0.5 ppm | USP2021 -- <251> | 0.05ppm |
| Arsenic (As) | NMT 1.0 ppm | USP2021 -- <211>Ⅱ | 0.02ppm |
| Mercury (Hg) | NMT 0.1 ppm | USP2021 -- <261> | 0.01ppm |
| Cadmium (Cd) | NMT 0.5 ppm | GB 5009.15 - 2014 | 0.01ppm |
| Organic volatile impurities | Meet the requirements | USP2021 -- <467>Ⅰ | Complies |
| Microbiological: | |||
| Total Aerobic | NMT 1,000cfu/g | USP2021 -- <2021> | <100 cfu/g |
| Yeast & Mold | NMT 100cfu/g | USP2021 -- <2021> | <30 cfu/g |
| E. coli | Negative in 1g | USP2021 -- <2022> | Negative |
| Salmonella | Negative in 10g | USP2021 -- <2022> | Negative |
| Staphylococcus Aureus | Negative in 1g | USP2021 -- <2022> | Negative |
| Enterobacteria & other gram neg | NMT 100cfu/g | USP2021 -- <2022> | <30 cfu/g |
| Packaging and Storage: | Store in tight, light - resistant containers under 25°C | ||
Function and Application:
1. D-Glucosamine hydrochloride can be made into drugs for the treatment of rheumatoid arthritis, ulcer disease, and enteritis, such as glucosamine chondroitin.Glucosamine hydrochloride powder can also be made into a nutrient additive for food and cosmetics, as well as a culture agent for biochemical cells.
2. Glucosamine is a kind of natural amino monosaccharides, which can stimulate chondrocytes to produce proteoglycans with normal multimeric structure, inhibit enzymes damaging cartilage, such as collagenase and phosphodiesterase A2, and prevent the production of superoxide radicals damaging the cells, thus it can slow down the disease of osteoarthritic pain.
3. Glucosamine HCL is extracted from natural crustacean, which is a kind of marine biological agent, can promote the synthesis of human mucopolysaccharide, improve the viscosity of synovial fluid, and can improve the metabolism of articular cartilage. Glucosamine bulk is widely available worldwide.
4. Glucosamine hydrochloride has the effect of promoting the effectiveness of antibiotic injection, used in the synthesis of water-soluble anticancer drug chlorourethromycin, which has the anticarcinogenicity of nitrosoureas, and at the same time has the characteristics of less toxicity of inhibiting bone marrow, and it shows a certain efficacy on melanoma, lung cancer, kidney cancer, etc..
Introduction：
Product Name | D-Glucosamine hydrochloride |
Synonyms | Glucosamine HCL |
Appearance | White crystalline powder |
CAS | 66-84-2 |
Molecular formula | C6H14ClNO5 |
Molecular Weight | 215.63 |
Purity | 98%min Glucosamine hydrochloride |
Sample | Available |
D-Glucosamine hydrochloride is a potentiator for the treatment of osteoarthritic diseases and antibiotics, a sweetener and antioxidant for food, a nutritional supplement for diabetic patients, and a major raw material for the synthesis of a new type of anticancer drug, Chlorourethromycin, which can also inhibit the growth of cancer cells. Glucosamine hydrochloride and its derivatives have a wide range of application prospects in the fields of medicine, light industry and cosmetics.
Specification:
| Items | Specifications | Test Methods | Results |
| Properties(physical): | |||
| Appearance | White Crystalline, Free Flowing Powder | Visual | Complies |
| Odour | Odourless | Complies | |
| Bulk Density | NLT 0.45g/ml | USP2021 -- <616> | 0.54g/ml |
| As Tapped Density | Meets the requirements of USP2021 | USP2021 -- <616> | Complies |
| Particle Size | NLT 90% through 80 Mesh | USP2021 -- <811> | Complies |
| Analytical Properties: | |||
| Assay(HPLC) | 98.0 - 102.0% (on the dried basis) | USP2021 -- <621> | 98.52% |
| Identification: | |||
| A: Infrared Absorption | Meet the requirement | USP2021 -- <197K> | Complies |
| B: Tests for Chloride | Meet the requirement | USP2021 -- <191> | Complies |
| C: Retention time in the Assay | Corresponds to the reference standard | USP2021 -- <621> | Complies |
| Transm | NLT 90.0% (10.0%Water Solutate-450nm) | USP2021 -- <857> | 96.8% |
| Absorb | NMT 0.25a.u. (10.0%Water Solutate-280nm) | USP2021 -- <857> | 0.05 a.u. |
| Specific Rotation (α)²⁰ᴰ | +70.00°→+73.00° | USP2021 -- <781S> | +71.69° |
| pH (20mg/ml.aq.sol.) | 3.0 - 5.0 | USP2021 -- <791> | 4.32 |
| Loss on Drying | NMT 0.5% | USP2021 -- <731> | 0.08% |
| Residue on Ignition | NMT 0.1% | USP2021 -- <281> | 0.06% |
| Chloride (Cl) | 16.0% - 17.0% | USP2021 -- <541> | 16.61% |
| Sulfate | NMT 0.24% | USP2021 -- <221> | Complies |
| Heavy Metals | NMT 10 ppm | USP2021 -- <231>Ⅱ | Complies |
| Iron (fe) | NMT 10 ppm | USP2021 -- <241> | Complies |
| Lead (Pb) | NMT 0.5 ppm | USP2021 -- <251> | 0.05ppm |
| Arsenic (As) | NMT 1.0 ppm | USP2021 -- <211>Ⅱ | 0.02ppm |
| Mercury (Hg) | NMT 0.1 ppm | USP2021 -- <261> | 0.01ppm |
| Cadmium (Cd) | NMT 0.5 ppm | GB 5009.15 - 2014 | 0.01ppm |
| Organic volatile impurities | Meet the requirements | USP2021 -- <467>Ⅰ | Complies |
| Microbiological: | |||
| Total Aerobic | NMT 1,000cfu/g | USP2021 -- <2021> | <100 cfu/g |
| Yeast & Mold | NMT 100cfu/g | USP2021 -- <2021> | <30 cfu/g |
| E. coli | Negative in 1g | USP2021 -- <2022> | Negative |
| Salmonella | Negative in 10g | USP2021 -- <2022> | Negative |
| Staphylococcus Aureus | Negative in 1g | USP2021 -- <2022> | Negative |
| Enterobacteria & other gram neg | NMT 100cfu/g | USP2021 -- <2022> | <30 cfu/g |
| Packaging and Storage: | Store in tight, light - resistant containers under 25°C | ||
Function and Application:
1. D-Glucosamine hydrochloride can be made into drugs for the treatment of rheumatoid arthritis, ulcer disease, and enteritis, such as glucosamine chondroitin.Glucosamine hydrochloride powder can also be made into a nutrient additive for food and cosmetics, as well as a culture agent for biochemical cells.
2. Glucosamine is a kind of natural amino monosaccharides, which can stimulate chondrocytes to produce proteoglycans with normal multimeric structure, inhibit enzymes damaging cartilage, such as collagenase and phosphodiesterase A2, and prevent the production of superoxide radicals damaging the cells, thus it can slow down the disease of osteoarthritic pain.
3. Glucosamine HCL is extracted from natural crustacean, which is a kind of marine biological agent, can promote the synthesis of human mucopolysaccharide, improve the viscosity of synovial fluid, and can improve the metabolism of articular cartilage. Glucosamine bulk is widely available worldwide.
4. Glucosamine hydrochloride has the effect of promoting the effectiveness of antibiotic injection, used in the synthesis of water-soluble anticancer drug chlorourethromycin, which has the anticarcinogenicity of nitrosoureas, and at the same time has the characteristics of less toxicity of inhibiting bone marrow, and it shows a certain efficacy on melanoma, lung cancer, kidney cancer, etc..